Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
Structure. 2022.
PMID: 35716663
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Functional insights from the crystal structure of the N-terminal domain of the prototypical toll receptor.
Structure. 2013.
PMID: 23245851
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Lipopolysaccharide Lewis Antigens.
In: Mobley HLT, Mendz GL, Hazell SL, editors. Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press; 2001. Chapter 35.
In: Mobley HLT, Mendz GL, Hazell SL, editors. Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press; 2001. Chapter 35.
PMID: 21290739
Free Books & Documents.
Review.
As determined by serological techniques, the O-antigen of lipopolysaccharide (LPS) of more than 80% of Helicobacter pylori strains tested worldwide express Lewis blood group antigens (36, 60, 71). This percentage possibly represents an underestimation; it was demonstrated …
As determined by serological techniques, the O-antigen of lipopolysaccharide (LPS) of more than 80% of Helicobacter pylori strains tested wo …
Structural basis for Lewis antigen synthesis by the alpha1,3-fucosyltransferase FUT9.
Nat Chem Biol. 2023 Aug;19(8):1022-1030. doi: 10.1038/s41589-023-01345-y. Epub 2023 May 18.
Nat Chem Biol. 2023.
PMID: 37202521
Free PMC article.
Terminal glycan structures include Lewis antigens synthesized by a collection of alpha1,3/4-fucosyltransferases (CAZy GT10 family). ...Here, we determined crystal structures of human FUT9, an alpha1,3-fucosyltransferase that generates Lewis(x) and L …
Terminal glycan structures include Lewis antigens synthesized by a collection of alpha1,3/4-fucosyltransferases (CAZy GT10 fam …
Electronic structure of mono(Lewis base)-stabilized borylenes.
Phys Chem Chem Phys. 2019 Nov 14;21(42):23533-23540. doi: 10.1039/c9cp04653d. Epub 2019 Oct 16.
Phys Chem Chem Phys. 2019.
PMID: 31617516
This work demonstrates that the mono(Lewis base)-stabilized three-center-six-electron (3c-6e) or LB B-R type borylenes may have a ground state singlet (sigma(2)pi(0) and sigma(0)pi(2)) or triplet (sigma(1)pi(1)) electronic structure, depending on the substitution gr …
This work demonstrates that the mono(Lewis base)-stabilized three-center-six-electron (3c-6e) or LB B-R type borylenes may have a gro …
Crystal structure of mango alpha1,3/alpha1,4-fucosyltransferase elucidates unique elements that regulate Lewis A-dominant oligosaccharide assembly.
Glycobiology. 2024 Apr 19;34(5):cwae015. doi: 10.1093/glycob/cwae015.
Glycobiology. 2024.
PMID: 38376259
In various organisms, alpha1,3/alpha1,4-fucosyltransferases (CAZy GT10 family enzymes) mediate the assembly of type I (Galbeta1,3GlcNAc) and/or type II (Galbeta1,4GlcNAc)-based Lewis structures that are widely distributed in glycoconjugates. ...In conclusion, we hav …
In various organisms, alpha1,3/alpha1,4-fucosyltransferases (CAZy GT10 family enzymes) mediate the assembly of type I (Galbeta1,3GlcNAc) and …
Conotoxins: Chemistry and Biology.
Chem Rev. 2019 Nov 13;119(21):11510-11549. doi: 10.1021/acs.chemrev.9b00207. Epub 2019 Oct 21.
Chem Rev. 2019.
PMID: 31633928
Review.
The rise of integrated venomics has accelerated conotoxin discovery with now well over 10,000 conotoxin sequences published. However, their structural and pharmacological characterization lags considerably behind. In this review, we highlight the diversity of new conotoxin …
The rise of integrated venomics has accelerated conotoxin discovery with now well over 10,000 conotoxin sequences published. However, their …
Synthesis of a Lewis b hexasaccharide thioglycoside donor and its use towards an extended mucin core Tn heptasaccharide structure and a photoreactive biotinylated serine linked hexasaccharide.
Org Biomol Chem. 2022 Jun 1;20(21):4431-4440. doi: 10.1039/d2ob00477a.
Org Biomol Chem. 2022.
PMID: 35587262
Investigation into Heliobacter pylori binding to Lewis b (Le(b)) antigens through the blood group antigen binding adhesion protein (BabA) requires structurally well-defined tools. ...This donor can be used to attach reducing end linkers providing a range of options …
Investigation into Heliobacter pylori binding to Lewis b (Le(b)) antigens through the blood group antigen binding adhesion protein (B …
Electronic transitions of molecules: vibrating Lewis structures.
Chem Sci. 2019 Jun 11;10(28):6809-6814. doi: 10.1039/c9sc02534k. eCollection 2019 Jul 28.
Chem Sci. 2019.
PMID: 31391902
Free PMC article.
Since the conception of the electron pair bond, Lewis structures have been used to illustrate the electronic structure of a molecule in its ground state. ...By partitioning the 3N-dimensional space of a many-electron wavefunction into hyper-regions related by …
Since the conception of the electron pair bond, Lewis structures have been used to illustrate the electronic structure …
Carbon-CArbon bond formation by Lewis superacid catalysis.
Chem Biodivers. 2014 Nov;11(11):1752-63. doi: 10.1002/cbdv.201400020.
Chem Biodivers. 2014.
PMID: 25408321
Review.
Diverse intramolecular cyclizations involving the formation of CC bonds are described using catalytic methodologies based on Lewis superacids. Examples are presented on 1,6-diene cyclizations to gem-dimethylcyclohexane structures. Tandem cyclization of trienes are d …
Diverse intramolecular cyclizations involving the formation of CC bonds are described using catalytic methodologies based on Lewis su …
Rotator cuff tendinopathy/subacromial impingement syndrome: is it time for a new method of assessment?
Br J Sports Med. 2009 Apr;43(4):259-64. doi: 10.1136/bjsm.2008.052183. Epub 2008 Oct 6.
Br J Sports Med. 2009.
PMID: 18838403
Generally these diagnostic labels relate more to a clinical hypothesis as to the underlying cause of the symptoms than to definitive evidence of the histological basis for the diagnosis or the correlation between structural failure and symptoms. Diagnosing rotator cuff ten …
Generally these diagnostic labels relate more to a clinical hypothesis as to the underlying cause of the symptoms than to definitive evidenc …
Pore structure of the Cys-loop ligand-gated ion channels.
Neurochem Res. 2009 Oct;34(10):1805-15. doi: 10.1007/s11064-009-9971-2. Epub 2009 Apr 19.
Neurochem Res. 2009.
PMID: 19381804
Review.
Here, we review the structural and biochemical data that form our understanding of the structure of the channel pore. ...The fundamental structural differences between anion and cation selective receptors and how these differences are related to the pore s …
Here, we review the structural and biochemical data that form our understanding of the structure of the channel pore. ...The f …
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